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Zirconia Based HPLC Columns

PBD (USP L49)

  • Great peak shapes for basic compounds

The surface chemistry of zirconia is very rich and may be used to change chemical selectivity of the column simply through the addition of mobile phase additives. Consider using ZirChrom®-PBD with a phosphate buffer if either the tailing of amines or their selectivities are problematic on C18 silica, and explore the full pH range (pH 1-14) to optimize your separation. For example, a 20 mM phosphate buffer will produce good peak shapes for many compounds.

CARB

ZirChrom®-CARB is great for geometric isomer separations, and is superb for separating diastereomers. The selectivity is more different from ODS than phenyl or cyano phases. This makes it an excellent choice for orthogonal screening in drug discovery and impurity profiling. Proper buffer selection helps to ensure the best peak shapes and band spacing.
ZirChrom®-CARB is stable from pH 1 – 14, and up to 200 °C.

C18

  • Ideal for separating steroids and analogues
  • Excellent selectivity for acidic compounds
  • pH stable from 1 – 14 for robust methods
  • Excellent thermal stability for fast separations

DiamondBond®-C18 is made by covalently bonding C18 ligands to the surface of carbon-clad zirconia. This creates the first truly bonded carbon phases in the industry. Because the surface below the C18 ligands is carbon and not silica, DiamondBond®-C18 has different selectivity from other phases. DiamondBond®-C18 has better peak shapes than unmodified carbon phases, and unique selectivity compared to silica phases. Life for all traditional reversed-phase zirconia products, proper buffer selection helps to ensure the best peak shapes and band spacing.

WAX (Stable from pH 3 – 9, and to 80 ºC)

  • Cross-linked polyethyleneimine-coated zirconia for weak anion-exchange
  • Efficient weak anion-exchanger useful for inorganic and organic anions
  • Useful for the separation of bio-molecules such as nucleotides, nuceosides, oligonucleotides,oligodeoxynucleotides, amino acids, peptides, and proteins
  • Extremely stable amino phase for normal phase separation of carbohydrates

SAX (Stable from pH 1 – 2, and to 80 ºC)

  • Cross-linked polyethyleneimine-coated zirconia for strong anion-exchange
  • Useful for inorganic and organic anions
  • Ideal for the separation of water-soluble vitamins
  • Useful for the separation of bio-molecules such as nucleotides, nucleosides, oligonucleotides, oligodeoxynucleotides, amino aicds, and peptides.
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