Plexa Polymeric SPE

Agilent Bond Elut Plexa Polymeric SPE

The Agilent Bond Elut Plexa family represents the next generation of polymeric solid phase extraction (SPE) technology, engineered for high reproducibility, simplified workflows, and superior extract cleanliness. With a hydroxylated outer surface and hydrophobic polymeric core, Plexa sorbents are uniquely structured to reduce matrix interferences and improve recovery precision.

Bond Elut Plexa

  • Fast flow rates for increased sample throughput and reproducible performance
  • Enhanced extract cleanliness minimizes matrix interferences and background noise
  • Non-polar retention mechanism ideal for neutral and hydrophobic analytes

Bond Elut Plexa PCX

  • Mixed-mode non-polar polymeric cation exchanger for selective analyte retention
  • Faster flow rates improve productivity and method efficiency
  • Cleaner extracts reduce interference, improving LC/MS accuracy and reproducibility
  • Single, simplified method format for easy implementation and reduced setup time

Bond Elut Plexa PAX

  • Mixed-mode non-polar polymeric anion exchanger for selective extraction of acidic analytes
  • Removes endogenous interferences to improve sensitivity and reduce ion suppression
  • Streamlined single-method workflow for consistent, high-throughput sample prep

For over 30 years, Agilent’s Bond Elut series has set the benchmark for quality in solid phase extraction. Its reliability and reproducibility are validated by more literature references than any other SPE brand worldwide. Each cartridge undergoes 25 rigorous quality control tests during fully automated manufacturing to ensure performance consistency.

The Bond Elut family offers over 40 different sorbent chemistries available in multiple formats— including straight barrel, large reservoir capacity (LRC), and Bond Elut Junior cartridges. While the classic Bond Elut C18 remains a popular choice for reversed-phase chromatography, the Plexa series provides enhanced analytical performance and versatility through its novel polymeric design.

Frequently Asked Questions

What is the main difference between Bond Elut Plexa, PCX, and PAX?

Bond Elut Plexa is a non-polar polymeric sorbent for general applications, while Plexa PCX and PAX are mixed-mode cation and anion exchangers designed for selective retention of charged analytes, offering cleaner extracts and reduced matrix effects.

What are the benefits of the Plexa polymeric architecture?

The hydroxylated surface prevents unwanted binding of proteins and phospholipids, while the hydrophobic interior improves analyte retention and elution efficiency, resulting in higher purity and recovery.

Are Bond Elut Plexa cartridges compatible with automation?

Yes. Bond Elut Plexa SPE cartridges are designed for compatibility with both manual and automated SPE systems, allowing seamless integration into high-throughput workflows.