Filters
Close
RSS

Blog

Successful Strategies for the Analysis of EtG and EtS in Urine

Liquor bottles on shelf

In a report by the National Highway Traffic Administration, it was found that an alcohol-impaired driver was involved in nearly one-third of all traffic crash fatalities. Impaired driving can result in several various penalties. Often times, the courts will order substance abuse evaluations, which can include a drug and alcohol urinalysis screening.             

Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are important biomarkers for monitoring alcohol use. For the court system, there are many advantages to using EtG and EtS, as a positive EtG result indicates that a person has recently been exposed to alcohol, up to three days, even when there is no longer ethanol detectable in the person’s system. According to Restek, EtG and EtS also provide good stability and analytical specificity, along with the long detection window.  

With the Restek Raptor EtG/EtS LC column, Restek has provided fast, 4-minute, dilute-and-shoot LC-MS/MS method that supports high sample throughput. Save time and increase certainty with the definitive EtG/EtS method.

Chromatogram

Sign Up for Our Newsletter

Chrom Tech is a Minnesota-based, worldwide distributor of chromatography instrumentation and supplies and mass spectrometry supplies. We carry vialswell platessyringe filterssolvent waste containers and all other critical chromatography and spectrometry supplies. Contact Chrom Tech  to become your preferred supplier of chromatography and mass spectrometry supplies.

Reduce PFAS Background Interference and Contamination in Your Agilent 1260/1290 Infinity II for PFAS Analyses

Header image of stream in the wilderness

According to the EPA, PFAS are persistent in the environment and human body, and exposure to these compounds can lead to adverse health effects. Per/Polyfluoroalkyl substances (PFAS), also known as perfluorinated compounds (PFCs), can be found in food, commercial household products, the workplace, drinking water, and even in living organisms. 

These are substances that have some or all the hydrogen atoms in an alkyl chain replaced by fluorine giving them uniquely desirable properties for use in industry and commerce. Their wide range of use is what has led to emission into the environment, and the need for analysis.

PFASs such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfanoic acid (PFOS) are ubiquitous, and have been detected in water, soil, sludge, and biota in the parts per billion (ppb) or parts per trillion (ppt) range. As a result, The USEPA has recently issued a combined drinking water health advisory for PFOA and PFOS at 70 ng/L. Several states such as New Jersey, New York, and North Carolina already have public health guideline values varying from 20–400 ng/L for several PFAS including PFOA, PFOS, perfluorohexanoic acid (PFHxA), and perfluorononanoic acid (PFNA) in water.

As denoted by Agilent, PFASs are routinely used in manufacturing processes, so it is possible to have system contamination in the solvents, tubing, fittings, filters, and other parts used in the manufacture and routine operation of a liquid chromatograph. Polytetrafluoroethylene (PTFE) is a fluoropolymer used in all major (U)HPLC systems, and can be a potential source of PFAS contamination during analysis. We provide a solution for reducing the potential sources of PFAS background interference contamination in an Agilent 1260 Infinity II and an Agilent 1290 Infinity II system, to allow sensitive quantification of these analytes.  

Chromatogram

Chromatogram 2

Sign Up for Our Newsletter

Chrom Tech is a Minnesota-based, worldwide distributor of chromatography instrumentation and supplies and mass spectrometry supplies. We carry vialswell platessyringe filterssolvent waste containers and all other critical chromatography and spectrometry supplies. Contact Chrom Tech  to become your preferred supplier of chromatography and mass spectrometry supplies.

Quantitative Analysis of 58 Antipsychotics and Antidepressants in Human Urine by LC-MS/MS

Prescription pills spilled out of bottle

The impact of human mental disorders continues to burden the health and wellness of people worldwide. As these disorders become more and more recognized in modern-day living, the number of prescribed antipsychotics (APs) and antidepressants (ADs) continues to increase. According to the CDC, over a fifteen-year time span, the use of antidepressants has increased nearly 65%.

These drugs are prescribed for a wide range of psychiatric disorders such as schizophrenia, bipolar disorder, dysthymia, social anxiety disorder, obsessive-compulsive disorder, and chronic pain. In the forensic setting, due to their abusive potential, the detection of these drugs is critical in determining their involvement in intoxications and suicides. 

In the clinical setting, analysis of APs and Ads in blood or urine is necessary to ensure suitable therapeutic concentration and to monitor patient compliance. It has been reported that the patient’s adherence to prescribed APs is quite low, and thus new clinical recommendations have been released regarding when and how to use urine testing procedures to help monitor adherence. By combining a simple sample preparation procedure and a fast chromatographic elution with the Raptor Biphenyl column, a highly specific and accurate method was established for simultaneous measurement of 28 Antipsychotics and 30 Antidepressant drugs in human urine.

Chromatogram

Sign Up for Our Newsletter

Chrom Tech is a Minnesota-based, worldwide distributor of chromatography instrumentation and supplies and mass spectrometry supplies. We carry vialswell platessyringe filterssolvent waste containers and all other critical chromatography and spectrometry supplies. Contact Chrom Tech  to become your preferred supplier of chromatography and mass spectrometry supplies.

Chrom Tech, Inc. Launches New Cannabis Chromatography Workflow Solutions Webstore

  Michelle Iverson, President, Chrom Tech, Inc.

Chrom Tech Expansion: Marketing to the Cannabis Testing Laboratories. 

A note from the President (and second-generation owner):

We are excited to announce the launch of our new webstore, cannabis.chromtech.com.  Our original site, chromtech.com has been around for 25 years and has over 30,000 products available. We continue to add resources and develop that site.  When deciding to enter the cannabis space, our goal was to have a webstore that was technical and easy to navigate.  We started by researching cannabis chromatography workflows and the associated application notes.  We achieved our goal by creating a boutique webstore cannabis.chromtech.com with specific cannabis chromatography workflows. 

Within each workflow, we carefully selected relevant products, thus minimizing confusion and maximizing efficiency for the person in the lab. With over 35 years in business, we have the infrastructure in place to serve the cannabis testing market with new insights.  We look forward to meeting with scientists in Portland, Oregon, as we exhibit at our first Cannabis Science Conference

Click here sales@chromtech.com to learn about new technical resources, products, and to be added to our list for new cannabis chromatography solutions.

Cleaner Rubber Septa for Better GC Analysis
Seal 2000 is specially formulated rubber compound. It has been found to minimize background interference for GC analysis. By reducing interfering peaks, Seal 2000 is recommended for clean and reliable GC results. View an experimental study comparing Seal 2000 and natural rubber.
We make safety compliance EASY with the Chrom Tech Solvent Waste Container System Kit!
Eliminate unnecessary safety risks, and avoid citations for improper waste containment by utilizing our waste containment system kit. A properly plumbed HPLC system, from inlet, to outlet, to waste is a crucial aspect in ensuring the safety of your laboratory’s employees.
Discover the right vial for your lab- New White Paper
Chrom Tech offers many options for vial and cap combinations. A general purpose vial will work for most labs, but occasionally a vial choice can greatly improve the flow in the workplace. We have a few suggestions to customers who have concerns with compatibility of their samples, or who experience problems with their autosamplers.
Chrom Tech is proud to carry Benchmark Scientific Products
Benchmark Scientific has been providing research laboratories with innovative, cost effective products and solutions designed to improve laboratory efficiency, safety and results.
Detecting Synthetic Opioids With an Agilent HPLC and Poroshell Column
Researchers use an Agilent HPLC and Poroshell Column to semi-automate synthetic opioid detection methods.