Intrada Amino Acids Separation Column

Imtakt Intrada Amino Acids Separation Column

The world’s first specialty column engineered for intact amino acid analysis by LC-MS—without derivatization.

  • Direct LC-MS analysis of amino acids—no derivatization required
  • High-purity 3 µm spherical silica designed specifically for amino acid separations

The Imtakt Intrada Amino Acid column delivers an advanced solution for fast, accurate, and derivatization-free amino acid profiling. Using a specialized silica phase optimized for zwitterionic analytes, Intrada provides exceptional retention control, reduced sample preparation time, and highly reproducible performance across a wide range of matrices.

This next-generation platform is ideal for high-throughput LC-MS workflows involving clinical amino acid biomarkers, fermentation products, nutritional supplements, botanical extracts, and other complex biological samples. Intrada enables analysts to achieve unmatched speed, selectivity, and convenience while maintaining the sensitivity required for modern amino acid quantitation.

Key Definitions ▸
Intact Amino Acid Analysis
A workflow in which amino acids are analyzed in their native form without chemical derivatization. Intrada enables direct LC-MS detection while preserving molecular integrity.
Derivatization-Free LC-MS
A simplified sample-prep approach that eliminates chemical modification steps. This reduces hands-on time, improves reproducibility, and avoids artifacts associated with derivatizing reagents.
Zwitterionic Analytes
Molecules such as amino acids that carry both positive and negative charges depending on pH. Specialized stationary phases, like Intrada’s engineered silica, retain these compounds with high selectivity and stability.
High-Throughput LC-MS
Analytical workflows optimized for rapid sample turnover and minimal preparation steps. Intrada supports fast cycle times while maintaining excellent resolution and sensitivity.
3 µm Spherical Silica
A high-purity, uniform particle technology used in the Intrada column to provide consistent flow paths, sharp peak shapes, and excellent reproducibility in amino acid separations.
Frequently Asked Questions ▸

Do I need to derivatize samples when using the Intrada Amino Acid column?

No. The Intrada column is specifically engineered for direct LC-MS analysis of intact amino acids, eliminating derivatization steps and simplifying sample preparation.

What types of samples are compatible with the Intrada Amino Acid column?

The column supports clinical biomarker analysis, fermented material profiling, botanical extracts, nutritional products, and other biological or biochemical matrices containing amino acids.

How does Intrada achieve reliable retention of zwitterionic amino acids?

Its specialized silica phase is designed to interact predictably with the dual charged nature of amino acids, providing stable retention, excellent peak shape, and consistent reproducibility across a wide range of pH conditions.