Precolumn Filters

IDEX Precolumn Filters provide reliable, low-dead-volume protection for analytical columns in both HPLC and UHPLC systems. Designed to trap particulates before they reach the column frit, these filters help preserve column efficiency, reduce downtime, and extend column lifetime in routine analytical workflows.

Available in both standard and biocompatible configurations, IDEX precolumn filters support multiple connection styles—including traditional designs that accept tubing on both sides and direct-connect versions that attach directly to the inlet port of most standard columns. All versions feature 10-32 coned ports for 1/16" OD tubing, enabling easy integration using common Fingertight fittings.

Standard Precolumn Filters

Standard precolumn filters deliver economical column protection for HPLC and UHPLC applications. Traditional versions allow tubing connections on both ends, while direct-connect models mount directly to the column inlet, minimizing extra fittings and simplifying system layouts. These filters provide a practical solution for capturing particulates while maintaining consistent chromatographic performance.

Biocompatible Precolumn Filters

Biocompatible precolumn filters are engineered for applications requiring inert flow paths and minimal sample interaction. Featuring 0.020" (0.50 mm) thru-holes and 8° distribution cones to reduce band broadening and improve mixing, these filters are manufactured from biocompatible PEEK and pressure rated up to 5,000 PSI (345 bar). Designed for use with 1/16" OD tubing, they provide dependable particulate protection while supporting sensitive bioanalytical workflows.

Chrom Tech stocks a wide selection of IDEX precolumn filters for fast shipment. Contact Chrom Tech for assistance selecting the right configuration for your column, pressure requirements, and application.

PART NO DESCRIPTION POROSITY THREADS SWEPT VOLUME PRESSURE RATING
REPLACEMENT PRECOLUMN MICROFILTER FRITS (FRIT DIAMETER × FRIT THICKNESS × OVERALL DIAMETER)
A-735x PEEK Frits, 0.045" × 0.031" × 0.192" 0.5 µm N/A 216 nL N/A
C-420 SST Frits, 0.038" × 0.028" × 0.192" 2 µm N/A 101 nL N/A
C-425 SST Frits, 0.038" × 0.028" × 0.192" 0.5 µm N/A 101 nL N/A
PRECOLUMN FILTERS
A-315 Solvent Filter Assy 2 µm 10-32 Coned 1.4 µL 6,000 PSI (414 bar)
A-316 Solvent Filter Assy 0.5 µm 10-32 Coned 1.3 µL 6,000 PSI (414 bar)
A-318 Solvent Filter Assy 0.5 µm 10-32 Coned 0.84 µL 6,000 PSI (414 bar)
A-101 Replacement Frits, Stainless Steel 2 µm — 0.74 µL N/A
A-102 Replacement Frits, Stainless Steel 0.5 µm — 0.61 µL N/A
BIOCOMPATIBLE PRECOLUMN FILTERS
A-355 Solvent Filter Assy 2 µm 10-32 Coned 1.4 µL 5,000 PSI (345 bar)
A-356 Solvent Filter Assy 0.5 µm 10-32 Coned 1.3 µL 5,000 PSI (345 bar)
A-700 Replacement Frit, PEEK Polymer, ea. 2 µm — 0.74 µL N/A
A-701 Replacement Frit, PEEK Polymer, ea. 0.5 µm — 0.61 µL N/A
Key Definitions ▶
Precolumn Filter
A compact inline filtration device installed upstream of an analytical column to capture particulates before they reach the column frit, helping protect column performance and extend column life.
Standard Precolumn Filter
A general-purpose precolumn filter designed for routine HPLC and UHPLC applications, available in traditional tubing-to-tubing configurations or direct-connect styles that attach directly to most column inlet ports.
Biocompatible Precolumn Filter
A PEEK-based precolumn filter engineered for bioanalytical workflows, offering inert flow paths, reduced sample interaction, and pressure ratings up to 5,000 PSI for sensitive applications.
Direct-Connect Precolumn Filter
A precolumn filter design that mounts directly to the inlet port of most standard columns, minimizing fittings and dead volume while simplifying system layouts.
10-32 Coned Port
A common fitting interface used with 1/16" OD tubing that provides reliable sealing in precolumn filters when paired with Fingertight or compression-style fittings.
Frequently Asked Questions ▶
What is the purpose of a precolumn filter?
Precolumn filters capture particulate matter before it reaches the analytical column, helping protect the column frit, maintain performance, and extend column lifetime in HPLC and UHPLC systems.
What’s the difference between standard and biocompatible precolumn filters?
Standard precolumn filters are designed for routine analytical workflows, while biocompatible versions are manufactured from PEEK for inert flow paths and reduced sample interaction—making them ideal for sensitive bioanalytical applications.
What is a direct-connect precolumn filter?
Direct-connect precolumn filters attach directly to the inlet port of most standard columns, reducing fittings and dead volume while simplifying system configuration.
What tubing size is supported?
All IDEX precolumn filters feature 10-32 coned ports designed for use with 1/16" OD tubing and standard Fingertight or compression fittings.
Are biocompatible precolumn filters suitable for UHPLC pressures?
Yes. Biocompatible IDEX precolumn filters are pressure rated up to 5,000 PSI (345 bar), making them suitable for many UHPLC and high-performance analytical workflows.