The Agilent ZORBAX Bonus-RP column has a polar amide group embedded in a long alkyl chain. This novel bonding reduces interactions between basic compounds and the silica support, improving peak shape for the most difficult basic compounds. The peak shape and column lifetime are further improved by the triple end-capping of Agilent’s Zorbax Bonus-RP HPLC columns. In addition, diisopropyl side groups provide steric protection against acid hydrolysis for good lifetime at low pH. The Agilent ZORBAX Bonus-RP column provides an alternate selectivity to C18 and C8 alkyl bonded phases.